Endocrine Abstracts

Introduction: Urinary iodine concentration (UIC) and neonatal thyroid stimulating hormone (neoTSH) concentrations can reflect changes in iodine status and serve as a sensitive marker of iodine intake in pregnancy. As gestational diabetes mellitus (GDM) requires some diet modification, the study aimed to map the situation of iodine intake in women with GDM compared to healthy pregnant women and explore a relationship to thyroid function.Methods: In the tw...

Background: Data on the effects of different dietary patterns on free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations are scarce. Our objective was to prospectively assess changes over time in these parameters and possible correlations with diet composition among overweight adults who followed a pescatarian Orthodox intermittent fasting (OF) regimen and controls who followed a low-fat 12:12 diet for 7 weeks.Methods: Tota...

Objective: Clinical trials aiming at strict glycemic control in high-risk patients with type 2 diabetes (T2DM) failed to show reduction in the incidence of cardiovascular events. The exact mechanisms remain unclear. We aimed to investigate the effect of intensive antidiabetic therapy on vascular indices of T2DM patients.Methods: We studied 62 T2DM patients [mean age 64 years, 52% males, mean T2DM duration 14 years) with poor glycemic control (HbA1c &#880...

Introduction: Polymorphisms of the receptor for advanced glycation end products (AGEs), RAGE, have been associated with autoimmune disorders and their complications. There are no studies concerning Hashimoto’s thyroiditis (HT); the aim of our study was to investigate the possible role of two RAGE polymorphisms (−429T>C, −374T>A) in combination with indices of oxidative status in women with HT.Design: We examined 300 euth...

ACTH test is widely accepted as diagnostic tool in suspicion on peripheral as well as on central hypocorticism. The optimal dose of tetracosactide for determination of hypocorticism is still matter of debate. The 250 μg as a standard dose of tetracosactide has been approved for diagnosis of congenital adrenal hyperplasia (CAH) many years ago. Moreover, current limited availability of tetracosactide and its increased financial cost on the market raised the question whether...

The aim of the study was a detailed analysis and a comparison of hypothalamic–pituitary–adrenal axis tests and cortisol metabolites analysis during these tests. This procedure might enable to design new diagnosis algorithms of hypocorticalism and normal levels for salivary cortisol estimation for early diagnostic of patients with hypothalamic–pituitary–adrenal axis disorder as well as to give us a possibility to reveal adrenal disorder in patients on estrog...

Background: Previous research has demonstrated positive effects of Orthodox fasting (OF) and time restricted eating (TRE) on body weight (BW). However, little is known about the late, metabolic effects of the two diets.Methods: 29 overweight adults followed a hypocaloric diet based on OF. A hypocaloric, TRE plan (eating between 08:00 to 16:00 h) was followed by 16 BW-matched participants. Anthropometric, glycemic and inflammation markers and serum lipids...

Objective: Androgen may be detrimental in the development of cardiovascular disease in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and thus the tissue androgen availability and early markers of atherosclerosis in apparently healthy women.Design and methods: In this prospective clinical study, 153 con...

Detailed information on adrenal function in autoimmune Type 1 diabetes with onset in adult age is still missing. This work compared diabetics with low response (LR) to diabetics with normal response (NR) to low dose ACTH test and control group (C).Thirty-two diabetics were investigated; LR (n=16), NR (n=16), age 44±10 years (mean±S.D.), age at diagnosis 28.5±10 years, disease duration 15±8 years, BMI 24.5&...

In female rats, diet enriched in advanced glycation end products (AGEs) has been associated with increased serum testosterone levels and deposition of dietary glycotoxins in ovarian tissue.Women with PCOS present increased serum AGE levels, which are acutely elevated after intake of a single meal high in AGE content. In this study the effects of a hypocaloric diet and an AGE-enriched hypocaloric diet were investigated, on the endocrine and metabolic prof...